Fat adherence syndrome treated with intraoperative mitomycin-C: A rabbit model

Steven E. Brooks, Gerald DeB. Ribeiro, Steven M. Archer, Victor M. Elner, Monte A. Del Monte

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We used an animal model of restrictive strabismus analogous to the fat adherence syndrome in humans to test the efficacy of topical Intraoperative mitomycin-C (MMC) in preventing the development of restrictive scar tissue. A cicatricial adhesion was created between the inferior rectus muscle and the inferior orbital rim of each eye in eight rabbits, and passive forced ductions were quantitatively measured with a spring scale. Eight eyes were treated Intraoperatively with topical MMC 0.5 mg/mL, the other eight with sterile water. Passive forced ductions were again measured 4 weeks postoperatively and representative orbits were exenterated for histopathologic examination. Significant restriction of motility was produced in six of the eight control eyes. Though prophylactic treatment with MMC may have been beneficial in some cases, on average, the restriction developing in these eyes did not significantly differ from that in the control eyes. In addition, longer exposure times to MMC led to marked orbital inflammation and severe restriction of ocular motility. Finally, histopathologic evaluation of the orbits of the MMC-treated eyes revealed marked fibrosis of perimuscular connective tissues. Although MMC may have a role in the management of fat adherence syndrome, further study is needed to establish safe and efficacious methods of delivery.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalJournal of Pediatric Ophthalmology and Strabismus
Issue number1
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology


Dive into the research topics of 'Fat adherence syndrome treated with intraoperative mitomycin-C: A rabbit model'. Together they form a unique fingerprint.

Cite this