Fertility in men with Klinefleter syndrome.

Christopher P. Houk, Alan Rogol, Peter A. Lee

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Klinefelter syndrome is an important cause of infertility among men. Although early development of the testes may appear normal, there is profound loss of germ cells during early-to-mid pubertal maturation. Spermatogenesis may be preserved in a small percent of tubules and these tubules may be available to artificial reproductive techniques for the retrieval and subsequent in vitro fertilization of extracted ova. Ethical and legal issues including risk-benefit consideration must be evaluated before implementing fertility preservation procedures in minors.

Original languageEnglish (US)
Pages (from-to)182-186
Number of pages5
JournalPediatric endocrinology reviews : PER
Volume8 Suppl 1
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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