Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

Sarah Eckenrode; Michele P. Marron; Robert Nicholls; Mark C.K. Yang; James J. Yang; Leticia C. Guida Fonseca; Jin Xiong She

doi:10.1007/s004399900186

Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

Sarah Eckenrode, Michele P. Marron, Robert Nicholls, Mark C.K. Yang, James J. Yang, Leticia C. Guida Fonseca, Jin Xiong She

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.

Original language	English (US)
Pages (from-to)	14-18
Number of pages	5
Journal	Human Genetics
Volume	106
Issue number	1
DOIs	https://doi.org/10.1007/s004399900186
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s004399900186

Cite this

@article{db37b8cc65c04cb895b3e10d8bf0b56b,

title = "Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses",

abstract = "Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.",

author = "Sarah Eckenrode and Marron, {Michele P.} and Robert Nicholls and Yang, {Mark C.K.} and Yang, {James J.} and {Guida Fonseca}, {Leticia C.} and She, {Jin Xiong}",

year = "2000",

doi = "10.1007/s004399900186",

language = "English (US)",

volume = "106",

pages = "14--18",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

AU - Eckenrode, Sarah

AU - Marron, Michele P.

AU - Nicholls, Robert

AU - Yang, Mark C.K.

AU - Yang, James J.

AU - Guida Fonseca, Leticia C.

AU - She, Jin Xiong

PY - 2000

Y1 - 2000

N2 - Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.

AB - Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.

UR - http://www.scopus.com/inward/record.url?scp=0034100050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034100050&partnerID=8YFLogxK

U2 - 10.1007/s004399900186

DO - 10.1007/s004399900186

M3 - Article

C2 - 10982176

AN - SCOPUS:0034100050

SN - 0340-6717

VL - 106

SP - 14

EP - 18

JO - Human Genetics

JF - Human Genetics

IS - 1

ER -

Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this