First HAART in HIV-infected patients with high viral load: Value of HIV RNA levels at 12 weeks to predict virologic outcome

David L Townsend; Jesús Troya; Ivana Maida; Leticia Pérez-Saleme; Giovanni Satta; Aimee Wilkin; Pablo Barreiro; P. Samuel Pegram; Vincent Soriano; Maria Stella Mura; Marina Núñez

doi:10.1177/1545109709343966

First HAART in HIV-infected patients with high viral load: Value of HIV RNA levels at 12 weeks to predict virologic outcome

David L Townsend, Jesús Troya, Ivana Maida, Leticia Pérez-Saleme, Giovanni Satta, Aimee Wilkin, Pablo Barreiro, P. Samuel Pegram, Vincent Soriano, Maria Stella Mura, Marina Núñez

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The aim of this study is to identify the role of incomplete suppression during the first months of highly active antiretroviral treatment (HAART) to predict virologic failure in patients with high levels of HIV replication. In a retrospective, longitudinal, and multicenter study, response to HAART was assessed in treatment-naive adults with HIV RNA >100 000 copies/mL, and factors predicting failure were analyzed through regression analyses. A total of 118 patients were included. Virologic failure occurred more often in patients with >500 copies/mL at week 12 (Cox regression: Exp (B) 3.22; P =.02). HIV RNA >500 copies/mL at week 12 predicted incomplete virologic response (odds ratio [OR] = 9.33; P =.002] but not viral rebound. Major antiretroviral resistant mutations were present in 11 of 14 patients. HIV RNA >500 copies/mL at week 12 of first HAART predicts incomplete virologic response in patients with high levels of replication at baseline. Most patients carried resistance mutations at the time of failure.

Original language	English (US)
Pages (from-to)	314-317
Number of pages	4
Journal	Journal of the International Association of Physicians in AIDS Care
Volume	8
Issue number	5
DOIs	https://doi.org/10.1177/1545109709343966
State	Published - Sep 1 2009

Keywords

HAART
HIV
high viral load
resistance mutations
virologic failure

ASJC Scopus subject areas

Immunology
Dermatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1545109709343966

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Townsend, D. L., Troya, J., Maida, I., Pérez-Saleme, L., Satta, G., Wilkin, A., Barreiro, P., Pegram, P. S., Soriano, V., Mura, M. S., & Núñez, M. (2009). First HAART in HIV-infected patients with high viral load: Value of HIV RNA levels at 12 weeks to predict virologic outcome. Journal of the International Association of Physicians in AIDS Care, 8(5), 314-317. https://doi.org/10.1177/1545109709343966

Townsend, DL, Troya, J, Maida, I, Pérez-Saleme, L, Satta, G, Wilkin, A, Barreiro, P, Pegram, PS, Soriano, V, Mura, MS & Núñez, M 2009, 'First HAART in HIV-infected patients with high viral load: Value of HIV RNA levels at 12 weeks to predict virologic outcome', Journal of the International Association of Physicians in AIDS Care, vol. 8, no. 5, pp. 314-317. https://doi.org/10.1177/1545109709343966

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abstract = "The aim of this study is to identify the role of incomplete suppression during the first months of highly active antiretroviral treatment (HAART) to predict virologic failure in patients with high levels of HIV replication. In a retrospective, longitudinal, and multicenter study, response to HAART was assessed in treatment-naive adults with HIV RNA >100 000 copies/mL, and factors predicting failure were analyzed through regression analyses. A total of 118 patients were included. Virologic failure occurred more often in patients with >500 copies/mL at week 12 (Cox regression: Exp (B) 3.22; P =.02). HIV RNA >500 copies/mL at week 12 predicted incomplete virologic response (odds ratio [OR] = 9.33; P =.002] but not viral rebound. Major antiretroviral resistant mutations were present in 11 of 14 patients. HIV RNA >500 copies/mL at week 12 of first HAART predicts incomplete virologic response in patients with high levels of replication at baseline. Most patients carried resistance mutations at the time of failure.",

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First HAART in HIV-infected patients with high viral load: Value of HIV RNA levels at 12 weeks to predict virologic outcome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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