Abstract
The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 785-788 |
| Number of pages | 4 |
| Journal | Archives of Oral Biology |
| Volume | 44 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1999 |
Keywords
- Biomarker
- Fluoride
- Metabolism
- Pharmacokinetics
- Plasma fluoride
- Salivary fluoride
ASJC Scopus subject areas
- Otorhinolaryngology
- General Dentistry
- Cell Biology