TY - JOUR
T1 - Fluoride-Induced Diuresis
T2 - Plasma Concentrations in the Rat
AU - Whitford, Gary M.
AU - Taves, Donald R.
N1 - Funding Information:
This paper supported in part by work performed under contract with the U.S. Atomic Energy Project and in part by the U.S. Public Health Service Training Grants GM-01781 and DE-00175 and has been assigned Report No. UR-49-1372. 6 1971 137 2 458 460
PY - 1971/6
Y1 - 1971/6
N2 - The rates of urine flow and the plasma fluoride concentrations were measured in anesthetized rats receiving continuous infusions of graded levels of fluoride in isotonic solutions. Infusion of 500 nmoles of fluoride/min produced the maximum diuresis, three times the mean control urine flow rate, and a plasma fluoride concentration of 272 μM. The 100 nmoles/min fluoride infusion rate produced an 80% increase in urine flow rate with a plasma fluoride concentration of 56 μM. These findings are consistent with estimates made for man and with the suggestion that the nephrotoxicity following methoxyflurane anesthesia is at least in part due to metabolism of methoxyflurane to inorganic fluoride.
AB - The rates of urine flow and the plasma fluoride concentrations were measured in anesthetized rats receiving continuous infusions of graded levels of fluoride in isotonic solutions. Infusion of 500 nmoles of fluoride/min produced the maximum diuresis, three times the mean control urine flow rate, and a plasma fluoride concentration of 272 μM. The 100 nmoles/min fluoride infusion rate produced an 80% increase in urine flow rate with a plasma fluoride concentration of 56 μM. These findings are consistent with estimates made for man and with the suggestion that the nephrotoxicity following methoxyflurane anesthesia is at least in part due to metabolism of methoxyflurane to inorganic fluoride.
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U2 - 10.3181/00379727-137-35599
DO - 10.3181/00379727-137-35599
M3 - Article
AN - SCOPUS:84970146530
SN - 1535-3702
VL - 137
SP - 458
EP - 460
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 2
ER -