Abstract
Purpose To assess the impact of single-dose fosaprepitant on nausea and emesis after BEAM and high-dose melphalan conditioning regimens for autologous hematopoietic stem cell transplantation. Methods In a single-center cohort study patients receiving melphalan containing hematopoietic stem cell transplantation regimens who received a one-time dose of 150 mg IV fosaprepitant (n = 56) were compared to a historical control (n = 70). Results The primary endpoint of no emesis from melphalan administration through five days afterward was 80% for the fosaprepitant group versus 66% in the control group (p = 0.068). Addition of fosaprepitant demonstrated significant improvement in emetic episodes per patient during the entire assessment period (p = 0.011) and days 1-5 after melphalan (p = 0.045). Fosaprepitant resulted in no substantial nausea during the entire assessment period in 37% of high-dose melphalan patients and 57% of BEAM patients. Conclusions Further studies are suggested to investigate the optimal number and timing of doses of fosaprepitant in this setting.
Original language | English (US) |
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Pages (from-to) | 416-422 |
Number of pages | 7 |
Journal | Journal of Oncology Pharmacy Practice |
Volume | 22 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2016 |
Externally published | Yes |
Keywords
- fosaprepitant
- hematopoietic stem cell transplant
- nausea
- vomiting
ASJC Scopus subject areas
- Oncology
- Pharmacology (medical)