From acute to maintenance: Strategies in the treatment of bipolar disorder

Established agents such as lithium, divalproex sodium, and carbamazepine have been in use for several decades for the treatment of bipolar disorder. Over the past few years, several new agents have become available, notably second-generation antipsychotic drugs. Although the ultimate goal of treatment in bipolar disease is to establish and sustain full remission, this is not always feasible. Providing symptomatic relief while minimizing adverse effects, preventing suicide, and ensuring an acceptable quality of life are appropriate and meaningful goals. The availability of a larger number of drugs that can be used for treatment of bipolar disorder should facilitate the achievement of these goals.