Abstract
The putative tumor suppressor Mst1, when cleaved to its 36 kDa cleaved form, amplifies apoptotic signals. We found that Mst1 was predominantly expressed in its full-length form in 76% (17/25 cases) of hepatocellular carcinoma (HCC) tumors. Mst1 cleavage was basically absent in HCC cells. Ectopic full-length Mst1 expression increased the growth of HCC cells by 55-80% within 3 days after transfection. Expression of exogenous NORE1B, a tumor suppressor commonly lost in HCC tumors (∼56% of our cohort), was sufficient to suppress the growth promotion of full-length Mst1. Hence, Mst1 exhibits a growth promoting activity in HCC cells upon NORE1B downregulation.
Original language | English (US) |
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Pages (from-to) | 496-503 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 587 |
Issue number | 5 |
DOIs | |
State | Published - Mar 1 2013 |
Externally published | Yes |
Keywords
- Akt
- Hep3B
- Huh7
- NORE1B
- PLC/PRF/5
- Staurosporine
- Stk4
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology