Fulminant hepatic failure: An unusual presentation of metastatic liver disease

Harold B. Harrison, Henry M. Middleton, John H. Crosby, M. Nesbit Dasher

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Over a 2-yr period, 3 patients with metastatic liver disease presented with a clinical course compatible with fulminant hepatic failure. The course was characterized by abdominal pain, jaundice, rapidly deteriorating mental status, high-serum enzyme values (SGOT, LDH, alkaline phosphatase), prolonged prothrombin times, and death within 1-12 days after hospitalization. At autopsy a similar histologic picture was present in each: extensive infiltration and replacement of liver by tumor and widespread infarction of remaining parenchyma. To place these 3 cases into a proper perspective, they were compared with 3 similar, previously reported cases (1 primary and 2 metastatic); and a retrospective autopsy review of metastatic liver disease occurring over a 4-yr period was performed. Fulminant hepatic failure due to extensive parenchymal infarction appears to represent an uncommon, but distinct entity in the overall spectrum of metastatic liver disease.

Original languageEnglish (US)
Pages (from-to)820-825
Number of pages6
Issue number4
StatePublished - Apr 1981
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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