Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration

Nilkantha Sen

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations


Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes, namely cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover, we highlighted the cross-talk between nitric oxide and H2S in several bilogical contexts.

Original languageEnglish (US)
Pages (from-to)543-561
Number of pages19
JournalJournal of Molecular Biology
Issue number4
StatePublished - Feb 17 2017
Externally publishedYes


  • CBS
  • CSE
  • hydrogen sulfide
  • sulfhydration

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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