@article{8aefd5f8f05045e8a1edeb429db6cdc9,
title = "Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon",
abstract = "Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.",
author = "Altrock, {Wilko D.} and {Tom Dieck}, Susanne and Maxim Sokolov and Meyer, {Alexander C.} and Albrecht Sigler and Cord Brakebusch and Reinhard F{\"a}ssler and Karin Richter and Boeckers, {Tobias M.} and Heidrun Potschka and Claudia Brandt and Wolfgang L{\"o}scher and D{\"o}rte Grimberg and Thomas Dresbach and Anne Hempelmann and Hadir Hassan and Detlef Balschun and Frey, {Julietta U.} and Brandst{\"a}tter, {Johann H.} and Garner, {Craig C.} and Christian Rosenmund and Gundelfinger, {Eckart D.}",
note = "Funding Information: This paper is dedicated to Kathrin Zobel, the most outstanding technician, who unexpectedly died while this work was in progress. We are grateful to K. Zobel, K. Hartung, B. Kracht, K. Schumacher, A. Hildebrand, I. Herfort, G.-S. Nam, and A. Rudloff for expert technical assistance; to F. Schmitz for advice on the quantification of EM data; J.L. Noebels for discussion of the epileptic phenotype; and O. Dick, B. Qualmann, J. Montgomery, and M. Kessels for many helpful discussions. This work was supported by the DFG SFB426 to E.D.G., J.U.F., S.t.D., and D.B.; SFB269 and Heisenberg Fellowships to J.H.B. and C.R.; the Fonds der Chemischen Industrie to E.D.G.; INTAS (Ref.-No. 97-10090) to J.U.F.; the Boehringer Ingelheim Fonds to A.C.M.; and the NIH (RO1 NS39471; PO1 AG06569; P50 HD32901) to C.C.G. ",
year = "2003",
month = mar,
day = "6",
doi = "10.1016/S0896-6273(03)00088-6",
language = "English (US)",
volume = "37",
pages = "787--800",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",
}