Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model

J. M. Kloss; D. S. Utley; D. J. Terris; D. H. Sierra

Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model

J. M. Kloss, D. S. Utley, D. J. Terris, D. H. Sierra

Research output: Contribution to conference › Paper › peer-review

Abstract

The rat sciatic nerve model was employed to evaluate collagen and brain derived neurotrophic factor (BDNF) used for peripheral nerve regeneration. The collagen tubule (CT)/linked-BDNF repair group demonstrated a statistically significant superior functional recovery compared to epineural coaptation (EC). Moreover CT/pumped-BDNF showed enhanced functional recovery compared to CT and EC. The CT/linked-BDNF repair group showed the largest mean axon diameters proximal and distal to the repair site. Repair groups that included both collagen tubulization and BDNF delivery improved the rate and the degree to which recovery of sciatic function occurs after nerve transection and repair.

Original language	English (US)
Number of pages	1
State	Published - Dec 1 1996
Externally published	Yes
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

Materials Science(all)

Cite this

@conference{b6d3e7b17bf545f2bb9e33674ced6d4a,

title = "Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model",

abstract = "The rat sciatic nerve model was employed to evaluate collagen and brain derived neurotrophic factor (BDNF) used for peripheral nerve regeneration. The collagen tubule (CT)/linked-BDNF repair group demonstrated a statistically significant superior functional recovery compared to epineural coaptation (EC). Moreover CT/pumped-BDNF showed enhanced functional recovery compared to CT and EC. The CT/linked-BDNF repair group showed the largest mean axon diameters proximal and distal to the repair site. Repair groups that included both collagen tubulization and BDNF delivery improved the rate and the degree to which recovery of sciatic function occurs after nerve transection and repair.",

author = "Kloss, {J. M.} and Utley, {D. S.} and Terris, {D. J.} and Sierra, {D. H.}",

year = "1996",

month = dec,

day = "1",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

}

TY - CONF

T1 - Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model

AU - Kloss, J. M.

AU - Utley, D. S.

AU - Terris, D. J.

AU - Sierra, D. H.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - The rat sciatic nerve model was employed to evaluate collagen and brain derived neurotrophic factor (BDNF) used for peripheral nerve regeneration. The collagen tubule (CT)/linked-BDNF repair group demonstrated a statistically significant superior functional recovery compared to epineural coaptation (EC). Moreover CT/pumped-BDNF showed enhanced functional recovery compared to CT and EC. The CT/linked-BDNF repair group showed the largest mean axon diameters proximal and distal to the repair site. Repair groups that included both collagen tubulization and BDNF delivery improved the rate and the degree to which recovery of sciatic function occurs after nerve transection and repair.

AB - The rat sciatic nerve model was employed to evaluate collagen and brain derived neurotrophic factor (BDNF) used for peripheral nerve regeneration. The collagen tubule (CT)/linked-BDNF repair group demonstrated a statistically significant superior functional recovery compared to epineural coaptation (EC). Moreover CT/pumped-BDNF showed enhanced functional recovery compared to CT and EC. The CT/linked-BDNF repair group showed the largest mean axon diameters proximal and distal to the repair site. Repair groups that included both collagen tubulization and BDNF delivery improved the rate and the degree to which recovery of sciatic function occurs after nerve transection and repair.

UR - http://www.scopus.com/inward/record.url?scp=0030421875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030421875&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030421875

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Functional recovery using cross-linked collagen tubulization for neurotrophic factor delivery in a rat peripheral nerve model

Abstract

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