Functionalized Diphenyl-Imidazolo-Pyrimidines

Pavel P. Lyubashov, Vyacheslav M. Povstyanoy, Andrey A. Krysko, Alexander Plotkin, Ilene Lovett, Mykhailo V. Povstyaniy, Iryna O. Lebedyeva

Research output: Contribution to journalArticlepeer-review


Synthesis of novel imidazopyrimidines has been reported. These systems contain carbethoxy group at C5 of pyrimidine and bromine at C2 of imidazole. Reactivity of these two groups was studied, and the mobility of the carbethoxy group was confirmed by tracing the formation of the amide product and also with isolation of alkyl analogs while bromine did not react with N-nucleophiles under various reaction conditions employed. New conjugates combine the properties of dihydropyrimidine and imidazole and therefore lead to the expansion of original properties of each heterocyclic moiety within the system.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalJournal of Heterocyclic Chemistry
Issue number1
StatePublished - Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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