Future directions in research on the epigenetics of aging

Charles W. Caldwell; Huidong Shi

doi:10.1007/978-1-4419-0639-7_24

Future directions in research on the epigenetics of aging

Charles W. Caldwell, Huidong Shi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epigenetics of aging is a new research direction that brings exciting and in-depth revelations in the near future. As reviewed in chapters throughout this book, aging is likely to be influenced by many complex interacting epigenetic factors. These include DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs. With the help of new technologies, particularly the knowledge derived from the genome-wide epigenomic studies, the upcoming years will be an exciting time to make breakthroughs in research on epigenetics of aging. Here we focus on several new directions in epigenetic research overall and their potential influence on aging research and the potential of anti-aging intervention using personalized, epigenetic-targeted pharmacologic agents.

Original language	English (US)
Title of host publication	Epigenetics of Aging
Publisher	Springer New York
Pages	433-446
Number of pages	14
ISBN (Electronic)	9781441906397
ISBN (Print)	9781441906380
DOIs	https://doi.org/10.1007/978-1-4419-0639-7_24
State	Published - Jan 1 2010
Externally published	Yes

Keywords

Aging
Epigenetic-targeted therapy
Epigenome

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4419-0639-7_24

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AB - Epigenetics of aging is a new research direction that brings exciting and in-depth revelations in the near future. As reviewed in chapters throughout this book, aging is likely to be influenced by many complex interacting epigenetic factors. These include DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs. With the help of new technologies, particularly the knowledge derived from the genome-wide epigenomic studies, the upcoming years will be an exciting time to make breakthroughs in research on epigenetics of aging. Here we focus on several new directions in epigenetic research overall and their potential influence on aging research and the potential of anti-aging intervention using personalized, epigenetic-targeted pharmacologic agents.

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KW - Epigenetic-targeted therapy

KW - Epigenome

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Future directions in research on the epigenetics of aging

Abstract

Keywords

ASJC Scopus subject areas

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