Future directions in research on the epigenetics of aging

Charles W. Caldwell, Huidong Shi

Research output: Chapter in Book/Report/Conference proceedingChapter


Epigenetics of aging is a new research direction that brings exciting and in-depth revelations in the near future. As reviewed in chapters throughout this book, aging is likely to be influenced by many complex interacting epigenetic factors. These include DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs. With the help of new technologies, particularly the knowledge derived from the genome-wide epigenomic studies, the upcoming years will be an exciting time to make breakthroughs in research on epigenetics of aging. Here we focus on several new directions in epigenetic research overall and their potential influence on aging research and the potential of anti-aging intervention using personalized, epigenetic-targeted pharmacologic agents.

Original languageEnglish (US)
Title of host publicationEpigenetics of Aging
PublisherSpringer New York
Number of pages14
ISBN (Electronic)9781441906397
ISBN (Print)9781441906380
StatePublished - Jan 1 2010
Externally publishedYes


  • Aging
  • Epigenetic-targeted therapy
  • Epigenome

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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