Ganglioside changes in slow virus diseases: Analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jacob agents

R. K. Yu; R. W. Ledeen; D. C. Gajdusek; C. J. Gibbs

doi:10.1016/0006-8993(74)90215-7

Ganglioside changes in slow virus diseases: Analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jacob agents

R. K. Yu, R. W. Ledeen, D. C. Gajdusek, C. J. Gibbs

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Brain gangliosides from chimpanzees infected with the viruses of kuru and Creutzfeldt-Jakob disease were isolated and subjected to quantitative and TLC analysis. Decreases of 40% and 25%, respectively, were found in total gray matter gangliosides. White matter of kuru showed a decline of 23%, whereas white matter of Creutzfeldt-Jakob disease showed an increase in total gangliosides amounting to 20% on a wet weight basis and 34% related to dry weight. TLC patterns were relatively normal for Creutzfeldt-Jakob disease except for possible slight decrease in G₁, G₂ and G_2A. The kuru pattern was abnormal with marked increase of G_3A in both white and gray matter and slight elevation of G₅ and G₆. G_2A did not increase, which marked a major difference from the previously reported pattern of subacute sclerosing panencephalitis (SSPE).

Original language	English (US)
Pages (from-to)	103-112
Number of pages	10
Journal	Brain Research
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(74)90215-7
State	Published - Apr 12 1974
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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@article{42c59ef4052e45f3ae423fed912f8a25,

title = "Ganglioside changes in slow virus diseases: Analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jacob agents",

abstract = "Brain gangliosides from chimpanzees infected with the viruses of kuru and Creutzfeldt-Jakob disease were isolated and subjected to quantitative and TLC analysis. Decreases of 40% and 25%, respectively, were found in total gray matter gangliosides. White matter of kuru showed a decline of 23%, whereas white matter of Creutzfeldt-Jakob disease showed an increase in total gangliosides amounting to 20% on a wet weight basis and 34% related to dry weight. TLC patterns were relatively normal for Creutzfeldt-Jakob disease except for possible slight decrease in G1, G2 and G2A. The kuru pattern was abnormal with marked increase of G3A in both white and gray matter and slight elevation of G5 and G6. G2A did not increase, which marked a major difference from the previously reported pattern of subacute sclerosing panencephalitis (SSPE).",

author = "Yu, {R. K.} and Ledeen, {R. W.} and Gajdusek, {D. C.} and Gibbs, {C. J.}",

note = "Funding Information: This research was supported by Grants NB-04834 and NB-03356 from the National Institutes of Health, U.S. Public Health Service, 669A from the National Multiple Sclerosis Society, and a grant from the Alfred P. Sloan Foundation.",

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doi = "10.1016/0006-8993(74)90215-7",

language = "English (US)",

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T2 - Analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jacob agents

AU - Yu, R. K.

AU - Ledeen, R. W.

AU - Gajdusek, D. C.

AU - Gibbs, C. J.

N1 - Funding Information: This research was supported by Grants NB-04834 and NB-03356 from the National Institutes of Health, U.S. Public Health Service, 669A from the National Multiple Sclerosis Society, and a grant from the Alfred P. Sloan Foundation.

PY - 1974/4/12

Y1 - 1974/4/12

N2 - Brain gangliosides from chimpanzees infected with the viruses of kuru and Creutzfeldt-Jakob disease were isolated and subjected to quantitative and TLC analysis. Decreases of 40% and 25%, respectively, were found in total gray matter gangliosides. White matter of kuru showed a decline of 23%, whereas white matter of Creutzfeldt-Jakob disease showed an increase in total gangliosides amounting to 20% on a wet weight basis and 34% related to dry weight. TLC patterns were relatively normal for Creutzfeldt-Jakob disease except for possible slight decrease in G1, G2 and G2A. The kuru pattern was abnormal with marked increase of G3A in both white and gray matter and slight elevation of G5 and G6. G2A did not increase, which marked a major difference from the previously reported pattern of subacute sclerosing panencephalitis (SSPE).

AB - Brain gangliosides from chimpanzees infected with the viruses of kuru and Creutzfeldt-Jakob disease were isolated and subjected to quantitative and TLC analysis. Decreases of 40% and 25%, respectively, were found in total gray matter gangliosides. White matter of kuru showed a decline of 23%, whereas white matter of Creutzfeldt-Jakob disease showed an increase in total gangliosides amounting to 20% on a wet weight basis and 34% related to dry weight. TLC patterns were relatively normal for Creutzfeldt-Jakob disease except for possible slight decrease in G1, G2 and G2A. The kuru pattern was abnormal with marked increase of G3A in both white and gray matter and slight elevation of G5 and G6. G2A did not increase, which marked a major difference from the previously reported pattern of subacute sclerosing panencephalitis (SSPE).

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Ganglioside changes in slow virus diseases: Analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jacob agents

Abstract

ASJC Scopus subject areas

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