Abstract
Insight on the function of gangliosides. can emerge from knowledge of their cellular distribution. In this paper we review the structure of ganglioside GD3 and recent information on its cellular distribution. GD3 appears to be enriched in a variety of neural cell types including: reactive glia, gliomas, undifferentiated neurons, Muller glia, and oligodendroglia. Because each of these cell types share an enhanced permeability to ions and metabolites or possess properties associated with enhanced permeability, we suggest that GD3 is associated with enhanced membrane permeability. A possible function for GD3 in membrane permeability has implications for other cellular events such as metabolism, growth and interactions.
Original language | English (US) |
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Pages (from-to) | 3-10 |
Number of pages | 8 |
Journal | Molecular and Cellular Biochemistry |
Volume | 68 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1985 |
Externally published | Yes |
Keywords
- development
- gangliosides
- gliomas
- membrane permeability
- mutant mice
- reactive glia
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology