Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting

Zhaohui Wang; Hongliang Hu; Jie Zheng; Biaoru Li

doi:10.1109/BIBE.2011.18

Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting

Zhaohui Wang
, Hongliang Hu
, Jie Zheng
, Biaoru Li

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.

Original language	English (US)
Title of host publication	Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Pages	72-77
Number of pages	6
DOIs	https://doi.org/10.1109/BIBE.2011.18
State	Published - 2011
Externally published	Yes
Event	2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 - Taichung, Taiwan, Province of China Duration: Oct 24 2011 → Oct 26 2011

Publication series

Name	Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011

Other

Other	2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Country/Territory	Taiwan, Province of China
City	Taichung
Period	10/24/11 → 10/26/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gene expression
pathway analysis
prevention targeting
quiescent CD8+ T cells
toxicogenomics

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1109/BIBE.2011.18

Cite this

Wang, Z., Hu, H., Zheng, J., & Li, B. (2011). Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 (pp. 72-77). Article 6089810 (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011). https://doi.org/10.1109/BIBE.2011.18

Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. / Wang, Zhaohui; Hu, Hongliang; Zheng, Jie et al.
Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 72-77 6089810 (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wang, Z, Hu, H, Zheng, J & Li, B 2011, Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. in Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011., 6089810, Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011, pp. 72-77, 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011, Taichung, Taiwan, Province of China, 10/24/11. https://doi.org/10.1109/BIBE.2011.18

Wang Z, Hu H, Zheng J, Li B. Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. p. 72-77. 6089810. (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011). doi: 10.1109/BIBE.2011.18

Wang, Zhaohui ; Hu, Hongliang ; Zheng, Jie et al. / Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : Study on toxicogenomics and prevention targeting. Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011. 2011. pp. 72-77 (Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011).

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abstract = "The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.",

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AB - The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.

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Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood: Study on toxicogenomics and prevention targeting

Abstract

Publication series

Other

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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