Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

Thomas N. Seyfried; Gilbert H. Glaser; Robert K. Yu

doi:10.1016/S0014-4886(84)90110-9

Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

Thomas N. Seyfried, Gilbert H. Glaser, Robert K. Yu

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Abstract: We previously proposed that the audiogenic seizure (AGS) susceptibility of 21 ± 1-day-old DBA/2 (D2) mice may result from an early postnatal elevation in serum thyroxine (T₄) concentration. In the present study we used seven C57 × DBA (BXD) recombinant inbred strains and the D2.B6-Ias^b congenic strain to study the association between serum T₄ content and susceptibility to AGS. The D2.B6-Ias^b congenic mice are genetically similar to the D2 mice except for the Ias^b gene, which inhibits AGS susceptibility. The total and estimated free serum T₄ concentrations in these strains at 14 ± 1 days of age were compared with the previously determined AGS susceptibilities of these strains at 21 ± 1 days of age. We found no significant correlations between serum T₄ concentration and AGS susceptibility in these strains. It is unlikely, therefore, that inherited differences in neonatal serum T₄ content are directly responsible for differences in susceptibility to AGS in 21 ± 1-day-old mice. The mechanisms by which the experimental manipulation of serum T₄ content influences AGS susceptibility are discussed.

Original language	English (US)
Pages (from-to)	423-428
Number of pages	6
Journal	Experimental Neurology
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/S0014-4886(84)90110-9
State	Published - Feb 1984
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1016/S0014-4886(84)90110-9

Cite this

@article{ddccbaea7efc4e94ab86488cfefd7c4f,

title = "Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice",

abstract = "Abstract: We previously proposed that the audiogenic seizure (AGS) susceptibility of 21 ± 1-day-old DBA/2 (D2) mice may result from an early postnatal elevation in serum thyroxine (T4) concentration. In the present study we used seven C57 × DBA (BXD) recombinant inbred strains and the D2.B6-Iasb congenic strain to study the association between serum T4 content and susceptibility to AGS. The D2.B6-Iasb congenic mice are genetically similar to the D2 mice except for the Iasb gene, which inhibits AGS susceptibility. The total and estimated free serum T4 concentrations in these strains at 14 ± 1 days of age were compared with the previously determined AGS susceptibilities of these strains at 21 ± 1 days of age. We found no significant correlations between serum T4 concentration and AGS susceptibility in these strains. It is unlikely, therefore, that inherited differences in neonatal serum T4 content are directly responsible for differences in susceptibility to AGS in 21 ± 1-day-old mice. The mechanisms by which the experimental manipulation of serum T4 content influences AGS susceptibility are discussed.",

author = "Seyfried, {Thomas N.} and Glaser, {Gilbert H.} and Yu, {Robert K.}",

note = "Funding Information: Abbreviations: T4-thyroxine, AGS-audiogenic seizure susceptibility, PTU-6-n-propyl-2-thiouracil, RI-recombinant inbred. {\textquoteright} This work was supported by grants from the U.S. Public Health Service (NS-17704, NS-11853), NMSS grant RGl289-B3, and the Swebilius Fund. T.N.S. was also supported by a Research Career Development Award (lK04NSOO59) from the U.S. Public Health Service. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1984",

month = feb,

doi = "10.1016/S0014-4886(84)90110-9",

language = "English (US)",

volume = "83",

pages = "423--428",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

AU - Seyfried, Thomas N.

AU - Glaser, Gilbert H.

AU - Yu, Robert K.

N1 - Funding Information: Abbreviations: T4-thyroxine, AGS-audiogenic seizure susceptibility, PTU-6-n-propyl-2-thiouracil, RI-recombinant inbred. ’ This work was supported by grants from the U.S. Public Health Service (NS-17704, NS-11853), NMSS grant RGl289-B3, and the Swebilius Fund. T.N.S. was also supported by a Research Career Development Award (lK04NSOO59) from the U.S. Public Health Service. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984/2

Y1 - 1984/2

N2 - Abstract: We previously proposed that the audiogenic seizure (AGS) susceptibility of 21 ± 1-day-old DBA/2 (D2) mice may result from an early postnatal elevation in serum thyroxine (T4) concentration. In the present study we used seven C57 × DBA (BXD) recombinant inbred strains and the D2.B6-Iasb congenic strain to study the association between serum T4 content and susceptibility to AGS. The D2.B6-Iasb congenic mice are genetically similar to the D2 mice except for the Iasb gene, which inhibits AGS susceptibility. The total and estimated free serum T4 concentrations in these strains at 14 ± 1 days of age were compared with the previously determined AGS susceptibilities of these strains at 21 ± 1 days of age. We found no significant correlations between serum T4 concentration and AGS susceptibility in these strains. It is unlikely, therefore, that inherited differences in neonatal serum T4 content are directly responsible for differences in susceptibility to AGS in 21 ± 1-day-old mice. The mechanisms by which the experimental manipulation of serum T4 content influences AGS susceptibility are discussed.

AB - Abstract: We previously proposed that the audiogenic seizure (AGS) susceptibility of 21 ± 1-day-old DBA/2 (D2) mice may result from an early postnatal elevation in serum thyroxine (T4) concentration. In the present study we used seven C57 × DBA (BXD) recombinant inbred strains and the D2.B6-Iasb congenic strain to study the association between serum T4 content and susceptibility to AGS. The D2.B6-Iasb congenic mice are genetically similar to the D2 mice except for the Iasb gene, which inhibits AGS susceptibility. The total and estimated free serum T4 concentrations in these strains at 14 ± 1 days of age were compared with the previously determined AGS susceptibilities of these strains at 21 ± 1 days of age. We found no significant correlations between serum T4 concentration and AGS susceptibility in these strains. It is unlikely, therefore, that inherited differences in neonatal serum T4 content are directly responsible for differences in susceptibility to AGS in 21 ± 1-day-old mice. The mechanisms by which the experimental manipulation of serum T4 content influences AGS susceptibility are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0021346436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021346436&partnerID=8YFLogxK

U2 - 10.1016/S0014-4886(84)90110-9

DO - 10.1016/S0014-4886(84)90110-9

M3 - Article

C2 - 6363115

AN - SCOPUS:0021346436

SN - 0014-4886

VL - 83

SP - 423

EP - 428

JO - Experimental Neurology

JF - Experimental Neurology

IS - 2

ER -

Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this