Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins

Gregory A Harshfield; Clarence E. Grim; Chun Hwang; Daniel D. Savage; Sandra J. Anderson

doi:10.1093/ajh/3.7.538

Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins

Gregory A Harshfield, Clarence E. Grim, Chun Hwang, Daniel D. Savage, Sandra J. Anderson

Research output: Contribution to journal › Article › peer-review

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Abstract

Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R²= 0.21; P <.01) and age (R²= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.

Original language	English (US)
Pages (from-to)	538-543
Number of pages	6
Journal	American journal of hypertension
Volume	3
Issue number	7
DOIs	https://doi.org/10.1093/ajh/3.7.538
State	Published - Jul 1990
Externally published	Yes

Keywords

Blacks
Deoxycorticosterone
Gene-environment interaction
Left ventricular hypertrophy
Left ventricular mass

ASJC Scopus subject areas

Internal Medicine

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10.1093/ajh/3.7.538

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title = "Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins",

abstract = "Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R2= 0.21; P <.01) and age (R2= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.",

keywords = "Blacks, Deoxycorticosterone, Gene-environment interaction, Left ventricular hypertrophy, Left ventricular mass",

author = "Harshfield, {Gregory A} and Grim, {Clarence E.} and Chun Hwang and Savage, {Daniel D.} and Anderson, {Sandra J.}",

note = "Funding Information: This research was supported in part by National Institutes of Health grants 7K04HL01885, HL42645, and Research Centers in Minority Institutions RR03026-02 and 878-F1 from the American Heart Association-Greater Los Angeles Affiliate.",

year = "1990",

month = jul,

doi = "10.1093/ajh/3.7.538",

language = "English (US)",

volume = "3",

pages = "538--543",

journal = "American journal of hypertension",

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T1 - Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins

AU - Harshfield, Gregory A

AU - Grim, Clarence E.

AU - Hwang, Chun

AU - Savage, Daniel D.

AU - Anderson, Sandra J.

N1 - Funding Information: This research was supported in part by National Institutes of Health grants 7K04HL01885, HL42645, and Research Centers in Minority Institutions RR03026-02 and 878-F1 from the American Heart Association-Greater Los Angeles Affiliate.

PY - 1990/7

Y1 - 1990/7

N2 - Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R2= 0.21; P <.01) and age (R2= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.

AB - Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R2= 0.21; P <.01) and age (R2= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.

KW - Blacks

KW - Deoxycorticosterone

KW - Gene-environment interaction

KW - Left ventricular hypertrophy

KW - Left ventricular mass

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Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins

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