Abstract
Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.
| Original language | English (US) |
|---|---|
| Title of host publication | Genomic and Precision Medicine |
| Subtitle of host publication | Cardiovascular Disease: Third Edition |
| Publisher | Elsevier Inc. |
| Pages | 197-219 |
| Number of pages | 23 |
| ISBN (Print) | 9780128018125 |
| DOIs | |
| State | Published - Jan 1 2018 |
Keywords
- Gene association studies
- Gene polymorphism
- Gene therapy
- Genome wide association studies
- Genomic methodology
- Haplotype
- Linkage disequilibrium
- Modifier gene
- Peripheral arterial disease
- Quantitative trait locus
- Single nucleotide polymorphism
- Therapeutic angiogenesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
