Genetics and Genomics of Peripheral Arterial Disease

Ayotunde O. Dokun; Brian H. Annex

doi:10.1016/B978-0-12-801812-5.00007-X

Genetics and Genomics of Peripheral Arterial Disease

Ayotunde O. Dokun, Brian H. Annex

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.

Original language	English (US)
Title of host publication	Genomic and Precision Medicine
Subtitle of host publication	Cardiovascular Disease: Third Edition
Publisher	Elsevier Inc.
Pages	197-219
Number of pages	23
ISBN (Print)	9780128018125
DOIs	https://doi.org/10.1016/B978-0-12-801812-5.00007-X
State	Published - Jan 1 2018

Keywords

Gene association studies
Gene polymorphism
Gene therapy
Genome wide association studies
Genomic methodology
Haplotype
Linkage disequilibrium
Modifier gene
Peripheral arterial disease
Quantitative trait locus
Single nucleotide polymorphism
Therapeutic angiogenesis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-801812-5.00007-X

Cite this

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title = "Genetics and Genomics of Peripheral Arterial Disease",

abstract = "Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.",

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AU - Annex, Brian H.

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AB - Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.

KW - Gene association studies

KW - Gene polymorphism

KW - Gene therapy

KW - Genome wide association studies

KW - Genomic methodology

KW - Haplotype

KW - Linkage disequilibrium

KW - Modifier gene

KW - Peripheral arterial disease

KW - Quantitative trait locus

KW - Single nucleotide polymorphism

KW - Therapeutic angiogenesis

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M3 - Chapter

SN - 9780128018125

SP - 197

EP - 219

BT - Genomic and Precision Medicine

PB - Elsevier Inc.

ER -

Genetics and Genomics of Peripheral Arterial Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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