TY - JOUR
T1 - Genome-wide gene expression profiles of the developing mouse hippocampus
AU - Mody, Monica
AU - Cao, Yanxiang
AU - Cui, Zhenzhong
AU - Tay, Khoon Yen
AU - Shyong, Andy
AU - Shimizu, Eiji
AU - Pham, Kelvin
AU - Schultz, Peter
AU - Welsh, Douglas
AU - Tsien, Joe Z.
PY - 2001/7/17
Y1 - 2001/7/17
N2 - We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.
AB - We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.
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U2 - 10.1073/pnas.141244998
DO - 10.1073/pnas.141244998
M3 - Article
C2 - 11438693
AN - SCOPUS:0035902553
SN - 0027-8424
VL - 98
SP - 8862
EP - 8867
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 15
ER -