Gestational sac aspiration: A novel alternative to Dilation and Evacuation for management of early pregnancy failure

Mohamed F. Mitwally, Hafsa Albuarki, Michael P. Diamond, Mostafa Abuzeid, Michael M. Fakih

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Study objective: To explore the effectiveness (success, safety, and complications) of a novel technique of gestational sac aspiration in the management of early pregnancy failure as an alternative to dilation and evacuation (D&E) and conservative management. Design: Prospective historical cohort study comparing effectiveness of gestational sac aspiration (study group) to conservative management (control group) with follow-up until negative quantitative beta human chorionic gonadotropin testing is achieved (Canadian Task Force classification II-1). Setting: An infertility treatment center. Patients: Among 60 women with failed early pregnancies that were achieved by in vitro fertilization or intrauterine insemination, 20 underwent gestational sac aspiration, whereas 40 chose conservative management. Interventions: Gestational sac aspiration was done by transvaginal ultrasound-guided needle aspiration under conscious sedation. Aspirated tissue was sent for karyotyping. Both study and control (conservative management) groups received close follow-up with ultrasound and serial beta human chorionic gonadotropin measurements. Measurements and main results: There was no significant difference in age, infertility factor, or treatment between study and control groups. Mean gestational age was 8 versus 6 weeks in study and control groups, respectively (p < .05). One and 11 patients required D&E in the study and control groups, respectively (p < .05). Karyotyping was successful in all except one patient in the study group. Chromosomal abnormalities were found in 36% of products of conception. No significant complications occurred. Conclusion: Gestational sac aspiration is a simple and safe outpatient technique that is more effective than conservative management of early pregnancy failure and less invasive than D&E. Moreover, the technique provides a high probability of obtaining a noncontaminated adequate gestation tissue sample for chromosomal study.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalJournal of Minimally Invasive Gynecology
Issue number4
StatePublished - Jul 1 2006
Externally publishedYes


  • Dilation and evacuation
  • Early pregnancy loss
  • Gestational sac aspiration
  • In vitro fertilization
  • Miscarriage

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Gestational sac aspiration: A novel alternative to Dilation and Evacuation for management of early pregnancy failure'. Together they form a unique fingerprint.

Cite this