Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2O3 Superparamagnetic Nanoparticles for Completely Killing Tumors

Jung Tak Jang, Jooyoung Lee, Jiyun Seon, Eric Ju, Minkyu Kim, Young Il Kim, Min Gyu Kim, Yasushi Takemura, Ali Syed Arbab, Keon Wook Kang, Ki Ho Park, Sun Ha Paek, Seongtae Bae

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (Happl·fappl < 3.0–5.0 × 109 A m−1 s−1), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe2O3 (Mg0.13-γFe2O3) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m2 kg−1, which is an ≈100 times higher than that of commercial Fe3O4 (Feridex, ILP = 0.15 nH m2 kg−1) at Happl·fappl = 1.23 × 109 A m−1 s−1 are reported. The significantly enhanced heat induction characteristics of Mg0.13-γFe2O3 are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg2+ cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe2O3 instead of well-known Fe3O4 SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg0.13-γFe2O3 nanofluids are conducted to estimate bioavailability and biofeasibility. Mg0.13-γFe2O3 nanofluids show promising hyperthermia effects to completely kill the tumors.

Original languageEnglish (US)
Article number1704362
JournalAdvanced Materials
Issue number6
StatePublished - Feb 8 2018


  • Mg-doped γ-FeO nanoparticles
  • cancer treatment
  • giant magnetic heat induction
  • intrinsic loss power
  • magnetic fluid hyperthermia

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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