Gingival recession defects and guided tissue regeneration: A review

Michael J. Danesh-Meyer, Ulf M E Wikesjö

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


The last decade has seen an increasing number of clinical reports on guided tissue regeneration (GTR) for reconstruction of gingival recession defects. This article reviews the value of GTR in the management of gingival recession defects based on records from such reports. Studies and case-series using nonresorbable and bioresorbable membranes, studies comparing GTR to the subepithelial connective tissue graft (CTG) procedure, and histologic reports of healing following GTR, published in the English language from 1985 to 2000, were identified using a Medline search and were included in the data-base for this review. The following pre-and post-treatment data were collated and evaluated for each of the reports: gingival recession depth, probing depth, clinical attachment level, and width of the keratinized gingiva. In perspective of the limitations of the studies reviewed, it has been shown that GTR may be used for reconstruction of gingival recession defects. Importantly, it has not been shown that GTR provides an added clinical benefit for the patient treatment planned for reconstruction of gingival recession defects, i.e. GTR does not appear to offer a significant advantage over mucogingival procedures such as the connective tissue graft or the advanced flap procedure. It is imperative to recognize inherent technical difficulties associated with GTR including primary wound closure and secondary membrane exposure; membrane exposures being negatively correlated to desired clinical outcomes. Also, membrane exposures appear consistently more common in smokers than in non-smokers. It is also imperative to recognize shortcomings and adverse effects including space maintenance and unacceptable foreign body reactions associated with some bioresorbable GTR technologies.

Original languageEnglish (US)
Pages (from-to)341-354
Number of pages14
JournalJournal of Periodontal Research
Issue number6
StatePublished - Dec 2001


  • Clinical trials, review
  • Gingival recession
  • Gingival/connective tissue graft
  • Guided tissue regeneration
  • Mucogingival procedures
  • Periodontal surgery
  • Rotational/advanced flap procedures

ASJC Scopus subject areas

  • Periodontics


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