TY - JOUR
T1 - Glass ionomer and composite resin cements
T2 - Effects on oral cells
AU - Caughman, W. Frank
AU - Caughman, Gretchen B.
AU - Dominy, Wilburn T.
AU - Schuster, George S.
N1 - Funding Information:
Thompson et al8 demonstrated that orthodontic bonding resins are not inert but the unpolymerized substances are cytotoxic. Hanks et a1.7i ndicated that the toxicity of BisGMA resins resulted from new toxic by-products pre- Presented at the American Academy of Crown and Bridge Prosthodontics meeting, Chicago, Ill. Supported by the American Academy of Crown and Bridge Prosthodontios and by NIH 5 TE35 DE-7143. *Associate Professor, Restorative Dentistry and Oral Biology/Mi-crobiology. **Associate Professor, Oral Biology/Microbiology. ***Dental student. ****Ione and Arthur Merritt Professor, Oral Biology/Microbiol-WY. 10/l/18287 cipitated during setting or residual toxic products from an incomplete reaction. There is a great variation in the composition and purity of commercial resin systems9a nd, combined with the conversion of the constituent monomers, they affect the properties of resins. The degree of conversion for autopolymerizing composite resins ranges from 529 %to 75 % ii resulting from the resin’sf ormulation, but the manipulation variables of light-polymerized composite resins also modify their conversion.
PY - 1990/5
Y1 - 1990/5
N2 - Because the cement interfaces of restorations can approximate the periodontium, it is critical to determine the biocompatibility of cements. In this study, the cytotoxic potential of resin luting agents on cultures of gingival fibroblasts and oral epithelial cells was evaluated for direct microscopic cytotoxicity, cell morbidity, impaired adherence, and inhibition of macromolecular synthesis. Visible effects ranged from severe toxicity with inadequately polymerized composite resin to no detectable morphologic cell damage by a glass ionomer cement, but inhibition of protein and RNA synthesis varied with the material and cell type. The glass ionomer cement demonstrated no morphologic damage, but exhibited inhibition of macromolecular synthesis in gingival fibroblasts. These results confirmed that in vitro metabolic assays are appropriate for examining the biologic effects of materials.
AB - Because the cement interfaces of restorations can approximate the periodontium, it is critical to determine the biocompatibility of cements. In this study, the cytotoxic potential of resin luting agents on cultures of gingival fibroblasts and oral epithelial cells was evaluated for direct microscopic cytotoxicity, cell morbidity, impaired adherence, and inhibition of macromolecular synthesis. Visible effects ranged from severe toxicity with inadequately polymerized composite resin to no detectable morphologic cell damage by a glass ionomer cement, but inhibition of protein and RNA synthesis varied with the material and cell type. The glass ionomer cement demonstrated no morphologic damage, but exhibited inhibition of macromolecular synthesis in gingival fibroblasts. These results confirmed that in vitro metabolic assays are appropriate for examining the biologic effects of materials.
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U2 - 10.1016/0022-3913(90)90067-M
DO - 10.1016/0022-3913(90)90067-M
M3 - Article
C2 - 2338664
AN - SCOPUS:0025425493
SN - 0022-3913
VL - 63
SP - 513
EP - 521
JO - The Journal of Prosthetic Dentistry
JF - The Journal of Prosthetic Dentistry
IS - 5
ER -