TY - JOUR
T1 - Global Disorders of Sex Development Update since 2006
T2 - Perceptions, Approach and Care
AU - Global DSD Update Consortium
AU - Lee, Peter A.
AU - Nordenström, Anna
AU - Houk, Christopher P.
AU - Ahmed, S. Faisal
AU - Auchus, Richard
AU - Baratz, Arlene
AU - Baratz Dalke, Katharine
AU - Liao, Lih Mei
AU - Lin-Su, Karen
AU - Looijenga, Leendert H.J.
AU - Mazur, Tom
AU - Meyer-Bahlburg, Heino F.L.
AU - Mouriquand, Pierre
AU - Quigley, Charmian A.
AU - Sandberg, David E.
AU - Vilain, Eric
AU - Witchel, Selma
N1 - Publisher Copyright:
© 2016 S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - The goal of this update regarding the diagnosis and care of persons with disorders of sex development (DSDs) is to address changes in the clinical approach since the 2005 Consensus Conference, since knowledge and viewpoints change. An effort was made to include representatives from a broad perspective including support and advocacy groups. The goal of patient care is focused upon the best possible quality of life (QoL). The field of DSD is continuously developing. An update on the clinical evaluation of infants and older individuals with ambiguous genitalia including perceptions regarding male or female assignment is discussed. Topics include biochemical and genetic assessment, the risk of germ cell tumor development, approaches to psychosocial and psychosexual well-being and an update on support groups. Open and on-going communication with patients and parents must involve full disclosure, with the recognition that, while DSD conditions are life-long, enhancement of the best possible outcome improves QoL. The evolution of diagnosis and care continues, while it is still impossible to predict gender development in an individual case with certainty. Such decisions and decisions regarding surgery during infancy that alters external genital anatomy or removes germ cells continue to carry risk.
AB - The goal of this update regarding the diagnosis and care of persons with disorders of sex development (DSDs) is to address changes in the clinical approach since the 2005 Consensus Conference, since knowledge and viewpoints change. An effort was made to include representatives from a broad perspective including support and advocacy groups. The goal of patient care is focused upon the best possible quality of life (QoL). The field of DSD is continuously developing. An update on the clinical evaluation of infants and older individuals with ambiguous genitalia including perceptions regarding male or female assignment is discussed. Topics include biochemical and genetic assessment, the risk of germ cell tumor development, approaches to psychosocial and psychosexual well-being and an update on support groups. Open and on-going communication with patients and parents must involve full disclosure, with the recognition that, while DSD conditions are life-long, enhancement of the best possible outcome improves QoL. The evolution of diagnosis and care continues, while it is still impossible to predict gender development in an individual case with certainty. Such decisions and decisions regarding surgery during infancy that alters external genital anatomy or removes germ cells continue to carry risk.
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U2 - 10.1159/000442975
DO - 10.1159/000442975
M3 - Review article
C2 - 26820577
AN - SCOPUS:84955596197
SN - 1663-2818
VL - 85
SP - 158
EP - 180
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
IS - 3
ER -
