Glycolipid Antigens in Neural Stem Cells

Yutaka Itokazu, Robert K. Yu

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The central nervous system, consisting of the brain and the spinal cord, is generated from progenitor cells that are generally recognized as neural stem cells (NSCs). NSCs are undifferentiated neural cells characterized by their high proliferative potential and capacity for self-renewal with retention of multipotency to differentiate into neurons and glia. Throughout neural development and cell differentiation, dynamic changes are observed in the composition of carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, that are expressed primarily on the outer surface of plasma membranes. The structural diversity of their carbohydrate moieties coupled with their unique spatial and temporal expression make these molecules excellent biomarkers for various cell types at different stages of development. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycolipids in NSCs and differentiation.

Original languageEnglish (US)
Title of host publicationNeural Surface Antigens
Subtitle of host publicationFrom Basic Biology Towards Biomedical Applications
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780128011263
ISBN (Print)9780128007815
StatePublished - Apr 15 2015


  • Cell surface microdomain
  • Epigenetics
  • Ganglioside
  • Gliogenesis
  • Glycoconjugate
  • Glycolipid
  • Glycosphingolipid
  • Neural stem cell
  • Neurogenesis

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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