TY - JOUR
T1 - Glycosignaling in neural stem cells
T2 - involvement of glycoconjugates in signal transduction modulating the neural stem cell fate.
AU - Yu, Robert K.
AU - Yanagisawa, Makoto
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2007/11
Y1 - 2007/11
N2 - The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.
AB - The mammalian CNS is organized by a variety of cells, such as neurons and glia, which are generated from neural stem cells (NSCs), undifferentiated neural cells characterized by their high proliferative potential while retaining their capacity for self- renewal and multipotency. Various signals from the environment, such as the 'niche,' modulate the fate of NSCs in their ability for self-renewal, proliferation, differentiation, and survival. There is increasing evidence that glycoconjugates, including proteoglycans, glycoproteins, and glycolipids, which are part of the plasma membrane glycocalyx network, are involved in mediation of these signals. In the present review, we discuss the roles of glycoconjugates in regulating the fate of NSCs and in supporting the underlying signal transduction mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=36448943234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36448943234&partnerID=8YFLogxK
U2 - 10.1111/j.1471-4159.2007.04710.x
DO - 10.1111/j.1471-4159.2007.04710.x
M3 - Review article
C2 - 17986138
AN - SCOPUS:36448943234
SN - 0022-3042
VL - 103 Suppl 1
SP - 39
EP - 46
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
ER -