Abstract
The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.
Original language | English (US) |
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Pages (from-to) | 679-684 |
Number of pages | 6 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 37 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1990 |
Externally published | Yes |
Keywords
- Cortical stroke
- GM1
- Ganglioside
- Ischemia
- Learning
- Memory
- Parietal
- Perseveration
- Stroke
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience