TY - JOUR
T1 - Granulocytic sarcoma of the pancreas
T2 - A report of two cases and literature review
AU - Ravandi-Kashani, F.
AU - Estey, E.
AU - Cortes, J.
AU - Medeiros, L. J.
AU - Giles, F. J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Granulocytic sarcomas (GS) are extramedullary tumour masses of immature myeloid cells, also known as chloroma and extramedullary myeloid cell tumour. These neoplasms usually occur simultaneously with, or follow the onset of, acute myeloid leukaemia (AML). Rarely, they are the first manifestation of AML. GS may also be the first sign of transformation to AML in patients with chronic myeloproliferative disorders and myelodysplastic syndromes. GS have been reported to occur in a variety of tissues, but presentation as an abdominal mass and, in particular, infiltration of the pancreas is rare. We report two cases of pancreatic GS, review the literature, and discuss recent insights into the basic biological properties of these rare turnouts.
AB - Granulocytic sarcomas (GS) are extramedullary tumour masses of immature myeloid cells, also known as chloroma and extramedullary myeloid cell tumour. These neoplasms usually occur simultaneously with, or follow the onset of, acute myeloid leukaemia (AML). Rarely, they are the first manifestation of AML. GS may also be the first sign of transformation to AML in patients with chronic myeloproliferative disorders and myelodysplastic syndromes. GS have been reported to occur in a variety of tissues, but presentation as an abdominal mass and, in particular, infiltration of the pancreas is rare. We report two cases of pancreatic GS, review the literature, and discuss recent insights into the basic biological properties of these rare turnouts.
KW - Chromosomal abnormalities
KW - Granulocytic sarcoma
KW - Pancreas
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U2 - 10.1046/j.1365-2257.1999.00205.x
DO - 10.1046/j.1365-2257.1999.00205.x
M3 - Article
C2 - 10448606
AN - SCOPUS:0032798645
SN - 0141-9854
VL - 21
SP - 219
EP - 224
JO - Clinical and Laboratory Haematology
JF - Clinical and Laboratory Haematology
IS - 3
ER -