Abstract
Spinal cord injury initiates a complex series of inflammatory and immune responses including the influx of monocytes, macrophages, T-cells, NK cells and so on, into the injured area. In the present study, we found a significant increase in the levels of granzyme-b (gra-b) from the first day after the transection until the third day, with decrease in intensity thereafter. The chemokine IP-10/CXCL10 was also found to be elevated along with gra-b correlating with the infiltration of CD-8+ cytotoxic T lymphocytes (CTLs) into the injured spinal cord. We observed an increase in the levels of the 64 kDa poly ADP ribose polymerase fragment, known to be a signature fragment produced by gra-b. Localization of gra-b in TUNEL positive neurons indicates that gra-b might play a crucial role in neuronal death and contributes to the pathophysiology of spinal cord injury.
Original language | English (US) |
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Pages (from-to) | 270-279 |
Number of pages | 10 |
Journal | Neuropathology |
Volume | 29 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2009 |
Externally published | Yes |
Keywords
- Cytotoxic T lymphocytes
- Granzyme-b
- IP-10/CXCL10
- PARP
- Spinal cord injury
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology