TY - JOUR
T1 - Gut-Immune-Kidney Axis
T2 - Influence of Dietary Protein in Salt-Sensitive Hypertension
AU - Mattson, David L.
AU - Dasinger, John Henry
AU - Abais-Battad, Justine M.
N1 - Funding Information:
The authors’ work is supported by NIH Grants HL137748, HL116264, 19CDA34660184, and the Georgia Research Alliance.
Publisher Copyright:
© 2022 American Heart Association, Inc.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared with normotensive subjects or those with salt-resistant hypertension. Substantial evidence from humans and animals has also demonstrated the role of dietary components other than salt to modulate hypertension. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of salt-sensitive hypertension and leads to malignant disease accompanied by end-organ damage. Interestingly, salt-sensitive disease is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, DNA methylation, gene expression, immune cell activation, the production of cytokines and other factors, and the development of salt-sensitive hypertension and related disease phenotypes.
AB - Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared with normotensive subjects or those with salt-resistant hypertension. Substantial evidence from humans and animals has also demonstrated the role of dietary components other than salt to modulate hypertension. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of salt-sensitive hypertension and leads to malignant disease accompanied by end-organ damage. Interestingly, salt-sensitive disease is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, DNA methylation, gene expression, immune cell activation, the production of cytokines and other factors, and the development of salt-sensitive hypertension and related disease phenotypes.
KW - cardiovascular diseases
KW - hypertension
KW - kidney
KW - lymphocytes
KW - microbiota
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U2 - 10.1161/HYPERTENSIONAHA.122.18556
DO - 10.1161/HYPERTENSIONAHA.122.18556
M3 - Review article
C2 - 35983758
AN - SCOPUS:85140363844
SN - 0194-911X
VL - 79
SP - 2397
EP - 2408
JO - Hypertension
JF - Hypertension
IS - 11
ER -