Gynecologic disorders and menstrual cycle lightheadedness in postural tachycardia syndrome

Kiffany J. Peggs, Hovan Nguyen, Diba Enayat, Nancy R. Keller, Ayman Al-Hendy, Satish R. Raj

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: To assess differences in gynecologic history and lightheadedness during menstrual cycle phases among patients with POTS and healthy control women. Methods: In a prospective, questionnaire-based study carried out at Paden Autonomic Dysfunction Center, Vanderbilt University, between April 2005 and January 2009, a custom-designed questionnaire was administered to patients with POTS (n = 65) and healthy individuals (n = 95). The results were analyzed via Fisher exact test and Mann-Whitney U test. Results: Patients with POTS reported increased lightheadedness through all phases of the menstrual cycle phases as compared with healthy controls. Both groups experienced the greatest lightheadedness during menses, and a decrease in lightheadedness during the follicular phase. Patients with POTS reported a higher incidence of gynecologic diseases as compared with healthy controls. Conclusion: The severity of lightheadedness was found to vary during the menstrual cycle, which may relate to changes in estrogen levels. Patients with POTS also reported an increase in estrogen-related gynecologic disease.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
StatePublished - Sep 2012
Externally publishedYes


  • Aldosterone
  • Estrogen
  • Lightheadedness
  • Menstrual cycle
  • Orthostatic tachycardia

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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