Abstract
During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.
Original language | English (US) |
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Pages (from-to) | 177-183 |
Number of pages | 7 |
Journal | Hemoglobin |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- Hematology
- Clinical Biochemistry
- Genetics(clinical)
- Biochemistry, medical