Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met

D. Plaseska; F. Kutlar; J. B. Wilson; B. B. Webber; Y. T. Zeng; T. H.J. Huisman

doi:10.3109/03630269009046959

Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;₂134(h12) val→met

D. Plaseska, F. Kutlar, J. B. Wilson, B. B. Webber, Y. T. Zeng, T. H.J. Huisman

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

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Abstract

During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal ^Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to ^Aγ was about 2 to 3; thus, Hb F with this variant ^Aγ chain appears to have approximately normal stability.

Original language	English (US)
Pages (from-to)	177-183
Number of pages	7
Journal	Hemoglobin
Volume	14
Issue number	2
DOIs	https://doi.org/10.3109/03630269009046959
State	Published - 1990

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

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title = "Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met",

abstract = "During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.",

author = "D. Plaseska and F. Kutlar and Wilson, {J. B.} and Webber, {B. B.} and Zeng, {Y. T.} and Huisman, {T. H.J.}",

note = "Funding Information: This study was supported in part by USPHS Research Grants HLB-05168 and HLB-41544. This is contribution #1212 from the Department o f Cell and Molecular Biology at the Medical College of Georgia i n Augusta, Georgia.",

year = "1990",

doi = "10.3109/03630269009046959",

language = "English (US)",

volume = "14",

pages = "177--183",

journal = "Hemoglobin",

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TY - JOUR

T1 - Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution

T2 - Αgamma;2134(h12) val→met

AU - Plaseska, D.

AU - Kutlar, F.

AU - Wilson, J. B.

AU - Webber, B. B.

AU - Zeng, Y. T.

AU - Huisman, T. H.J.

N1 - Funding Information: This study was supported in part by USPHS Research Grants HLB-05168 and HLB-41544. This is contribution #1212 from the Department o f Cell and Molecular Biology at the Medical College of Georgia i n Augusta, Georgia.

PY - 1990

Y1 - 1990

N2 - During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.

AB - During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.

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Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;₂134(h12) val→met

Abstract

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