Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

T. Harano; K. Harano; K. Doi; S. Ueda; K. Imai; Y. Ohba; Ferdane Kutlar; T. H.J. Huisman

doi:10.3109/03630269009046964

Hb f-onoda or α2^gγ2¹⁴⁶(^HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

T. Harano, K. Harano, K. Doi, S. Ueda, K. Imai, Y. Ohba, Ferdane Kutlar, T. H.J. Huisman

Pulmonary Disease

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Abstract

During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the ^Gγ type. We named it Hb F-Onoda [α₂^Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Hemoglobin
Volume	14
Issue number	2
DOIs	https://doi.org/10.3109/03630269009046964
State	Published - 1990

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

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@article{9f198ce78b574904bed8dacc86187e39,

title = "Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn",

abstract = "During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.",

author = "T. Harano and K. Harano and K. Doi and S. Ueda and K. Imai and Y. Ohba and Ferdane Kutlar and Huisman, {T. H.J.}",

note = "Funding Information: The authors wish to thank Miss R. Uenaka, School of Medicine, Osaka University, for her technical assistance. This study was i n part supported by USPHS Research Grant HLB-05168. This i s contribution #1179 from the Department of Cell and Molecular Biology a t the Medical College of Georgia i n Augusta, Georgia.",

year = "1990",

doi = "10.3109/03630269009046964",

language = "English (US)",

volume = "14",

pages = "217--222",

journal = "Hemoglobin",

issn = "0363-0269",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

AU - Harano, T.

AU - Harano, K.

AU - Doi, K.

AU - Ueda, S.

AU - Imai, K.

AU - Ohba, Y.

AU - Kutlar, Ferdane

AU - Huisman, T. H.J.

N1 - Funding Information: The authors wish to thank Miss R. Uenaka, School of Medicine, Osaka University, for her technical assistance. This study was i n part supported by USPHS Research Grant HLB-05168. This i s contribution #1179 from the Department of Cell and Molecular Biology a t the Medical College of Georgia i n Augusta, Georgia.

PY - 1990

Y1 - 1990

N2 - During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

AB - During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

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U2 - 10.3109/03630269009046964

DO - 10.3109/03630269009046964

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AN - SCOPUS:0025180094

SN - 0363-0269

VL - 14

SP - 217

EP - 222

JO - Hemoglobin

JF - Hemoglobin

IS - 2

ER -

Hb f-onoda or α2^gγ2¹⁴⁶(^HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

Abstract

ASJC Scopus subject areas

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