Hb J-Antakya or α2β265(E9)Lys → Met in a Turkish family and Hb Complutense or α2β2127(H5)Gln → Glu in a Spanish family; correction of a previously published identification

Titus H.J. Huisman; Jerry B. Wilson; Abdullah Kutlar; Ke gong Yang; Song sen Chen; Brooke B. Webber; Cigdem Altay; Ana Villegas Martinez

doi:10.1016/0167-4838(86)90178-0

Hb J-Antakya or α₂β₂65(E9)Lys → Met in a Turkish family and Hb Complutense or α₂β₂127(H5)Gln → Glu in a Spanish family; correction of a previously published identification

Titus H.J. Huisman, Jerry B. Wilson, Abdullah Kutlar, Ke gong Yang, Song sen Chen, Brooke B. Webber, Cigdem Altay, Ana Villegas Martinez

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Almost 10 years ago we reported in this journal the characterization of Hb Hacettepe or α₂β₂127(H5)Gln → Glu. Unfortunately, we have to conclude that the original characterization of this Turkish variant was in error. The corrected data are presented in this short communication. The variant (α₂β₂65(E9)Lys → Met) was (re)named Hb J-Antakya, after the city where the family resides. An abnormal Hb, observed in a Spanish family and named Hb Complutense, had the β127 Gln → Glu substitution, erroneously assigned to the Turkish variant.

Original language	English (US)
Pages (from-to)	229-231
Number of pages	3
Journal	Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
Volume	871
Issue number	2
DOIs	https://doi.org/10.1016/0167-4838(86)90178-0
State	Published - Jun 5 1986

Keywords

(Human hemoglobin)
Amino acid substitution
Hb Complutense
Hb Hacettepe
Hb J-Antakya
Hemoglobin variant

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Molecular Biology

Access to Document

10.1016/0167-4838(86)90178-0

Cite this

Huisman, T. H. J., Wilson, J. B., Kutlar, A., Yang, K. G., Chen, S. S., Webber, B. B., Altay, C., & Martinez, A. V. (1986). Hb J-Antakya or α₂β₂65(E9)Lys → Met in a Turkish family and Hb Complutense or α₂β₂127(H5)Gln → Glu in a Spanish family; correction of a previously published identification. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 871(2), 229-231. https://doi.org/10.1016/0167-4838(86)90178-0

Hb J-Antakya or α₂β₂65(E9)Lys → Met in a Turkish family and Hb Complutense or α₂β₂127(H5)Gln → Glu in a Spanish family; correction of a previously published identification. / Huisman, Titus H.J.; Wilson, Jerry B.; Kutlar, Abdullah et al.
In: Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, Vol. 871, No. 2, 05.06.1986, p. 229-231.

Research output: Contribution to journal › Article › peer-review

Huisman, THJ, Wilson, JB, Kutlar, A, Yang, KG, Chen, SS, Webber, BB, Altay, C & Martinez, AV 1986, 'Hb J-Antakya or α₂β₂65(E9)Lys → Met in a Turkish family and Hb Complutense or α₂β₂127(H5)Gln → Glu in a Spanish family; correction of a previously published identification', Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, vol. 871, no. 2, pp. 229-231. https://doi.org/10.1016/0167-4838(86)90178-0

Huisman THJ, Wilson JB, Kutlar A, Yang KG, Chen SS, Webber BB et al. Hb J-Antakya or α₂β₂65(E9)Lys → Met in a Turkish family and Hb Complutense or α₂β₂127(H5)Gln → Glu in a Spanish family; correction of a previously published identification. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1986 Jun 5;871(2):229-231. doi: 10.1016/0167-4838(86)90178-0

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title = "Hb J-Antakya or α2β265(E9)Lys → Met in a Turkish family and Hb Complutense or α2β2127(H5)Gln → Glu in a Spanish family; correction of a previously published identification",

abstract = "Almost 10 years ago we reported in this journal the characterization of Hb Hacettepe or α2β2127(H5)Gln → Glu. Unfortunately, we have to conclude that the original characterization of this Turkish variant was in error. The corrected data are presented in this short communication. The variant (α2β265(E9)Lys → Met) was (re)named Hb J-Antakya, after the city where the family resides. An abnormal Hb, observed in a Spanish family and named Hb Complutense, had the β127 Gln → Glu substitution, erroneously assigned to the Turkish variant.",

keywords = "(Human hemoglobin), Amino acid substitution, Hb Complutense, Hb Hacettepe, Hb J-Antakya, Hemoglobin variant",

author = "Huisman, {Titus H.J.} and Wilson, {Jerry B.} and Abdullah Kutlar and Yang, {Ke gong} and Chen, {Song sen} and Webber, {Brooke B.} and Cigdem Altay and Martinez, {Ana Villegas}",

note = "Funding Information: This research was in part supported by USPH Research grant HLB-05168. This is contribution No. 0958 of the Department of Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia.",

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AU - Huisman, Titus H.J.

AU - Wilson, Jerry B.

AU - Kutlar, Abdullah

AU - Yang, Ke gong

AU - Chen, Song sen

AU - Webber, Brooke B.

AU - Altay, Cigdem

AU - Martinez, Ana Villegas

N1 - Funding Information: This research was in part supported by USPH Research grant HLB-05168. This is contribution No. 0958 of the Department of Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia.

PY - 1986/6/5

Y1 - 1986/6/5

N2 - Almost 10 years ago we reported in this journal the characterization of Hb Hacettepe or α2β2127(H5)Gln → Glu. Unfortunately, we have to conclude that the original characterization of this Turkish variant was in error. The corrected data are presented in this short communication. The variant (α2β265(E9)Lys → Met) was (re)named Hb J-Antakya, after the city where the family resides. An abnormal Hb, observed in a Spanish family and named Hb Complutense, had the β127 Gln → Glu substitution, erroneously assigned to the Turkish variant.

AB - Almost 10 years ago we reported in this journal the characterization of Hb Hacettepe or α2β2127(H5)Gln → Glu. Unfortunately, we have to conclude that the original characterization of this Turkish variant was in error. The corrected data are presented in this short communication. The variant (α2β265(E9)Lys → Met) was (re)named Hb J-Antakya, after the city where the family resides. An abnormal Hb, observed in a Spanish family and named Hb Complutense, had the β127 Gln → Glu substitution, erroneously assigned to the Turkish variant.

KW - (Human hemoglobin)

KW - Amino acid substitution

KW - Hb Complutense

KW - Hb Hacettepe

KW - Hb J-Antakya

KW - Hemoglobin variant

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