Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant

J. J. Malcorra-Azpiazu; H. I. Balda-Aguirre; J. C. Diaz-Chico; H. Hu; J. B. Wilson; B. B. Webber; F. Kutlar; A. Kutlar; T. H.J. Huisman

doi:10.3109/03630268808998022

Hb las palms or α₂β₂49(cd8)ser→phe, a mildly unstable hemiglobin variant

J. J. Malcorra-Azpiazu
, H. I. Balda-Aguirre
, J. C. Diaz-Chico
, H. Hu
, J. B. Wilson
, B. B. Webber
, F. Kutlar
, A. Kutlar
, T. H.J. Huisman

Pulmonary Disease

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

Original language	English (US)
Pages (from-to)	163-170
Number of pages	8
Journal	Hemoglobin
Volume	12
Issue number	2
DOIs	https://doi.org/10.3109/03630268808998022
State	Published - 1988

ASJC Scopus subject areas

Hematology
Genetics(clinical)
Clinical Biochemistry
Biochemistry, medical

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10.3109/03630268808998022

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title = "Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant",

abstract = "A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43\% and 45\% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.",

author = "Malcorra-Azpiazu, \{J. J.\} and Balda-Aguirre, \{H. I.\} and Diaz-Chico, \{J. C.\} and H. Hu and Wilson, \{J. B.\} and Webber, \{B. B.\} and F. Kutlar and A. Kutlar and Huisman, \{T. H.J.\}",

note = "Funding Information: This research was supported by USPHS Research Grants HLB-05168 and HLB-15158. Dr. J.C. Diaz-Chico was supported by Gobierno Auto-nomo de Canarias y Caja de Ahorros de Canarias. This is contribution \#lo65 from the Department of Cell and Molecular Biology at the Medical College o f Georgia i n Augusta, Georgia.",

year = "1988",

doi = "10.3109/03630268808998022",

language = "English (US)",

volume = "12",

pages = "163--170",

journal = "Hemoglobin",

issn = "0363-0269",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant

AU - Malcorra-Azpiazu, J. J.

AU - Balda-Aguirre, H. I.

AU - Diaz-Chico, J. C.

AU - Hu, H.

AU - Wilson, J. B.

AU - Webber, B. B.

AU - Kutlar, F.

AU - Kutlar, A.

AU - Huisman, T. H.J.

N1 - Funding Information: This research was supported by USPHS Research Grants HLB-05168 and HLB-15158. Dr. J.C. Diaz-Chico was supported by Gobierno Auto-nomo de Canarias y Caja de Ahorros de Canarias. This is contribution #lo65 from the Department of Cell and Molecular Biology at the Medical College o f Georgia i n Augusta, Georgia.

PY - 1988

Y1 - 1988

N2 - A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

AB - A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

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U2 - 10.3109/03630268808998022

DO - 10.3109/03630268808998022

M3 - Article

C2 - 3384708

AN - SCOPUS:0023877087

SN - 0363-0269

VL - 12

SP - 163

EP - 170

JO - Hemoglobin

JF - Hemoglobin

IS - 2

ER -

Hb las palms or α₂β₂49(cd8)ser→phe, a mildly unstable hemiglobin variant

Abstract

ASJC Scopus subject areas

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