TY - JOUR
T1 - Heart rate variability in left ventricular Hypertrophy
AU - Mandawat, Mahendra K.
AU - Wallbridge, David R.
AU - Pringle, Stuart D.
AU - Riyami, Abdulla A S
AU - Latif, Shahid
AU - MacFarlane, Peter W.
AU - Lorimer, A. Ross
AU - Cobbe, Stuart M.
PY - 1995
Y1 - 1995
N2 - Background-Electrocardiographic left ventricular hypertrophy and strain are associated with increased cardiac morbidity and mortality. Impaired cardiac autonomic function, assessed noninvasively by spontaneous heart rate variability on Holter monitoring, is associated with an increased risk of sudden death after myocardial infarction. Aim-To study the effect of left ventricular hypertrophy on heart rate variability. Patients-36 controls and 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease). Setting-Tertiary referral centre. Methods-Heart rate variability was measured on 24 h Holter recordings by non-spectral methods. Left ventricular mass index and fractional shortening were measured by echocardiography. Results-Patients with left ventricular hypertrophy had a higher left ventricular mass index (P < 0.001) and reduced heart rate variability (P< 0.001) compared with those of the controls. A continuous inverse relation was apparent between heart rate variability and left ventricular mass index (r = - 0.478, P < 0.001). Heart rate variability was not affected by age, the presence of coronary artery disease in patients with left ventricular hypertrophy, or β blocker treatment for hypertension. Multivariate analysis showed that left ventricular mass index is the most important determinant of heart rate variability. Conclusion-Heart rate variability is significantly reduced in patients with left ventricular hypertrophy secondary to hypertension or aortic valve disease. A continuous inverse relation exists between heart rate variability and left ventricular mass index. Impaired cardiac autonomic function in left ventricular hypertrophy may contribute to the mechanism of sudden death.
AB - Background-Electrocardiographic left ventricular hypertrophy and strain are associated with increased cardiac morbidity and mortality. Impaired cardiac autonomic function, assessed noninvasively by spontaneous heart rate variability on Holter monitoring, is associated with an increased risk of sudden death after myocardial infarction. Aim-To study the effect of left ventricular hypertrophy on heart rate variability. Patients-36 controls and 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease). Setting-Tertiary referral centre. Methods-Heart rate variability was measured on 24 h Holter recordings by non-spectral methods. Left ventricular mass index and fractional shortening were measured by echocardiography. Results-Patients with left ventricular hypertrophy had a higher left ventricular mass index (P < 0.001) and reduced heart rate variability (P< 0.001) compared with those of the controls. A continuous inverse relation was apparent between heart rate variability and left ventricular mass index (r = - 0.478, P < 0.001). Heart rate variability was not affected by age, the presence of coronary artery disease in patients with left ventricular hypertrophy, or β blocker treatment for hypertension. Multivariate analysis showed that left ventricular mass index is the most important determinant of heart rate variability. Conclusion-Heart rate variability is significantly reduced in patients with left ventricular hypertrophy secondary to hypertension or aortic valve disease. A continuous inverse relation exists between heart rate variability and left ventricular mass index. Impaired cardiac autonomic function in left ventricular hypertrophy may contribute to the mechanism of sudden death.
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U2 - 10.1136/hrt.73.2.139
DO - 10.1136/hrt.73.2.139
M3 - Article
C2 - 7696023
AN - SCOPUS:0028874271
SN - 1355-6037
VL - 73
SP - 139
EP - 144
JO - Heart
JF - Heart
IS - 2
ER -