TY - JOUR
T1 - Hematopoiesis. Clinical application of colony-stimulating factors
AU - Janik, John Edward
AU - Miller, Langdon L.
PY - 1997
Y1 - 1997
N2 - The deleterious effects of chemotherapy on normal hematopoietic tissues may produce severe or protracted deficiencies in red blood cells, neutrophils, or platelets, and result in life-threatening infection or bleeding. Hematopoietic growth factors have had a profound influence on the management of patients undergoing cancer chemotherapy. Three recombinant hematopoietic growth factors have been licensed for clinical use in the United States: erythropoietin, G-CSF, and GM-CSF. Erythropoietin reduces the transfusion requirements of chemotherapy-induced anemia, and G-CSF and GM-CSF prevent infections due to chemotherapy-induced neutropenia, shorten the duration of neutropenia following high-dose chemotherapy, and stem cell transplantation and mobilize stem cells for transplantation. This chapter reviews randomized placebo-controlled trials of the licensed colony-stimulating factors in management of patients with cancer and briefly examines new agents that stimulate megakaryocyte and platelet development.
AB - The deleterious effects of chemotherapy on normal hematopoietic tissues may produce severe or protracted deficiencies in red blood cells, neutrophils, or platelets, and result in life-threatening infection or bleeding. Hematopoietic growth factors have had a profound influence on the management of patients undergoing cancer chemotherapy. Three recombinant hematopoietic growth factors have been licensed for clinical use in the United States: erythropoietin, G-CSF, and GM-CSF. Erythropoietin reduces the transfusion requirements of chemotherapy-induced anemia, and G-CSF and GM-CSF prevent infections due to chemotherapy-induced neutropenia, shorten the duration of neutropenia following high-dose chemotherapy, and stem cell transplantation and mobilize stem cells for transplantation. This chapter reviews randomized placebo-controlled trials of the licensed colony-stimulating factors in management of patients with cancer and briefly examines new agents that stimulate megakaryocyte and platelet development.
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U2 - 10.1016/S1874-5687(97)80006-7
DO - 10.1016/S1874-5687(97)80006-7
M3 - Review article
AN - SCOPUS:0040715619
SN - 1874-5687
VL - 3
SP - 157
EP - 189
JO - Growth Factors and Cytokines in Health and Disease
JF - Growth Factors and Cytokines in Health and Disease
IS - C
ER -
