Hematopoiesis. Clinical application of colony-stimulating factors

John Edward Janik, Langdon L. Miller

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The deleterious effects of chemotherapy on normal hematopoietic tissues may produce severe or protracted deficiencies in red blood cells, neutrophils, or platelets, and result in life-threatening infection or bleeding. Hematopoietic growth factors have had a profound influence on the management of patients undergoing cancer chemotherapy. Three recombinant hematopoietic growth factors have been licensed for clinical use in the United States: erythropoietin, G-CSF, and GM-CSF. Erythropoietin reduces the transfusion requirements of chemotherapy-induced anemia, and G-CSF and GM-CSF prevent infections due to chemotherapy-induced neutropenia, shorten the duration of neutropenia following high-dose chemotherapy, and stem cell transplantation and mobilize stem cells for transplantation. This chapter reviews randomized placebo-controlled trials of the licensed colony-stimulating factors in management of patients with cancer and briefly examines new agents that stimulate megakaryocyte and platelet development.

Original languageEnglish (US)
Pages (from-to)157-189
Number of pages33
JournalGrowth Factors and Cytokines in Health and Disease
Issue numberC
StatePublished - 1997

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Cancer Research


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