Hematopoietic cell regulation of osteoblast proliferation and differentiation

Monique Bethel, Edward F. Srour, Melissa A. Kacena

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lineage. For example, OBs are important players in the hematopoietic stem cell (HSC) niche and OBs are known to impact osteoclast (OC) development. Thus, although much is known regarding the impact OBs have on hematopoietic cells, less is known about the impact of hematopoietic cells on OBs. Here we will review this reciprocal relationship: the effects of hematopoietic cells on OBs. Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell-derived OCs on OB proliferation, differentiation, and function.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalCurrent Osteoporosis Reports
Issue number2
StatePublished - Jun 2011
Externally publishedYes


  • B cells
  • Differentiation
  • Hematopoiesis
  • Hematopoietic stem cells
  • Megakaryocytes
  • Osteoblasts
  • Osteoclasts
  • Proliferation
  • T cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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