Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)

Ryan C. Johnson; Natasha M. Savage; Tsoyu Chiang; Jason R. Gotlib; Athena M. Cherry; Daniel A. Arber; Tracy I. George

doi:10.1309/AJCP1Q0YSXEAHNKK

Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)

Ryan C. Johnson, Natasha M. Savage, Tsoyu Chiang, Jason R. Gotlib, Athena M. Cherry, Daniel A. Arber, Tracy I. George

Clinical Pathology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Results: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. Conclusions: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.

Original language	English (US)
Pages (from-to)	525-535
Number of pages	11
Journal	American Journal of Clinical Pathology
Volume	140
Issue number	4
DOIs	https://doi.org/10.1309/AJCP1Q0YSXEAHNKK
State	Published - Oct 2013

Keywords

AML with t(8;21)
CD25
D816V
Exon 17 KIT mutations
Myelomastocytic leukemia
N822K
Systemic mastocytosis
Tryptase

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/AJCP1Q0YSXEAHNKK

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title = "Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)",

abstract = "Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Results: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. Conclusions: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.",

keywords = "AML with t(8;21), CD25, D816V, Exon 17 KIT mutations, Myelomastocytic leukemia, N822K, Systemic mastocytosis, Tryptase",

author = "Johnson, {Ryan C.} and Savage, {Natasha M.} and Tsoyu Chiang and Gotlib, {Jason R.} and Cherry, {Athena M.} and Arber, {Daniel A.} and George, {Tracy I.}",

year = "2013",

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language = "English (US)",

volume = "140",

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AU - Johnson, Ryan C.

AU - Savage, Natasha M.

AU - Chiang, Tsoyu

AU - Gotlib, Jason R.

AU - Cherry, Athena M.

AU - Arber, Daniel A.

AU - George, Tracy I.

PY - 2013/10

Y1 - 2013/10

N2 - Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Results: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. Conclusions: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.

AB - Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Results: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. Conclusions: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.

KW - AML with t(8;21)

KW - CD25

KW - D816V

KW - Exon 17 KIT mutations

KW - Myelomastocytic leukemia

KW - N822K

KW - Systemic mastocytosis

KW - Tryptase

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Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)

Abstract

Keywords

ASJC Scopus subject areas

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