High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

Xiaohong He; Xiaofei Chen; Wenbin Zhang; Yabin Pu; Shen Song; Jianlin Han; Kunzhe Dong; Qianjun Zhao; Weijun Guan; Yuehui Ma; Lin Jiang

doi:10.1080/24701394.2016.1197219

High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

Xiaohong He, Xiaofei Chen, Wenbin Zhang, Yabin Pu, Shen Song, Jianlin Han, Kunzhe Dong, Qianjun Zhao, Weijun Guan, Yuehui Ma, Lin Jiang

Research output: Contribution to journal › Article › peer-review

Abstract

Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.

Original language	English (US)
Pages (from-to)	851-854
Number of pages	4
Journal	Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis
Volume	28
Issue number	6
DOIs	https://doi.org/10.1080/24701394.2016.1197219
State	Published - Nov 2 2017
Externally published	Yes

Keywords

Bactrian camel
control region
length heteroplasmy
mitochondrial DNA

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1080/24701394.2016.1197219

Cite this

@article{4d5b41da9a0143f6bfb224fac3e4221c,

title = "High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)",

abstract = "Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.",

keywords = "Bactrian camel, control region, length heteroplasmy, mitochondrial DNA",

author = "Xiaohong He and Xiaofei Chen and Wenbin Zhang and Yabin Pu and Shen Song and Jianlin Han and Kunzhe Dong and Qianjun Zhao and Weijun Guan and Yuehui Ma and Lin Jiang",

note = "Publisher Copyright: {\textcopyright} 2016 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2017",

month = nov,

day = "2",

doi = "10.1080/24701394.2016.1197219",

language = "English (US)",

volume = "28",

pages = "851--854",

journal = "Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis",

issn = "2470-1394",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

AU - He, Xiaohong

AU - Chen, Xiaofei

AU - Zhang, Wenbin

AU - Pu, Yabin

AU - Song, Shen

AU - Han, Jianlin

AU - Dong, Kunzhe

AU - Zhao, Qianjun

AU - Guan, Weijun

AU - Ma, Yuehui

AU - Jiang, Lin

PY - 2017/11/2

Y1 - 2017/11/2

N2 - Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.

AB - Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.

KW - Bactrian camel

KW - control region

KW - length heteroplasmy

KW - mitochondrial DNA

UR - http://www.scopus.com/inward/record.url?scp=85004074746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85004074746&partnerID=8YFLogxK

U2 - 10.1080/24701394.2016.1197219

DO - 10.1080/24701394.2016.1197219

M3 - Article

C2 - 27937010

AN - SCOPUS:85004074746

SN - 2470-1394

VL - 28

SP - 851

EP - 854

JO - Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis

JF - Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis

IS - 6

ER -

High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this