Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)

Christopher J. Lynch, Gurmukh Singh, Theresa L. Whiteside, Gerald P. Rodnan, Thomas A. Medsger, Bruce S. Rabin

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls;P<0.005, corrected P>0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls;P<0.005, corrected P<0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P<0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR1-negative patients (0.46 vs 0.18;P<0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype or HLA-DR5 antigen.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalJournal of Clinical Immunology
Issue number4
StatePublished - Oct 1 1982
Externally publishedYes


  • HLA antigens in PSS
  • Progressive systemic sclerosis (PSS)
  • histocompatibility antigens
  • scleroderma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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