TY - JOUR
T1 - History of gestational diabetes, insulin resistance and coronary risk
AU - Davis, Catherine L.
AU - Gutt, Miriam
AU - Llabre, Maria M.
AU - Marks, Jennifer B.
AU - O'Sullivan, Mary J.
AU - Potter, Jonell E.
AU - Landel, Julie L.
AU - Kumar, Mahendra
AU - Schneiderman, Neil
AU - Gellman, Marc
AU - Skyler, Jay S.
N1 - Funding Information:
This investigation was supported by NIH-NHLBI grants P01 HL36588 and T32 HL07426.
PY - 1999/7
Y1 - 1999/7
N2 - The purpose of this study was to examine characteristics associated with the insulin metabolic syndrome, including insulin resistance, abnormal glucose tolerance, dyslipidemia, obesity, and elevated blood pressure, among women who have experienced gestational diabetes. 39 nondiabetic, young (20-42 years), postpartum (3-18 months) white women were recruited from obstetrical clinics. Twenty-one women had a history of gestational diabetes; 18 had uncomplicated pregnancies. Multivariate analyses revealed a significant difference between groups in insulin resistance (M, measured by euglycemic clamp) and insulin levels (from an oral glucose tolerance test), with insulin resistance showing a statistically stronger difference than insulin levels. Groups also differed significantly when compared on a set of variables associated with insulin metabolic syndrome: glucose tolerance, triglycerides, blood pressure, and body-mass index. Using insulin resistance as a covariate eliminated these group differences, suggesting that insulin resistance is the key factor underlying insulin metabolic syndrome. The higher risk of later developing type 2 diabetes and hypertension in women who have a history of gestational diabetes is explicable by their poorer profile on variables associated with insulin metabolic syndrome, and appears to be attributable to insulin resistance. Thus, insulin resistance appears to distinguish young women at risk for cardiovascular disease. Copyright (C) 1999 Elsevier Science Inc.
AB - The purpose of this study was to examine characteristics associated with the insulin metabolic syndrome, including insulin resistance, abnormal glucose tolerance, dyslipidemia, obesity, and elevated blood pressure, among women who have experienced gestational diabetes. 39 nondiabetic, young (20-42 years), postpartum (3-18 months) white women were recruited from obstetrical clinics. Twenty-one women had a history of gestational diabetes; 18 had uncomplicated pregnancies. Multivariate analyses revealed a significant difference between groups in insulin resistance (M, measured by euglycemic clamp) and insulin levels (from an oral glucose tolerance test), with insulin resistance showing a statistically stronger difference than insulin levels. Groups also differed significantly when compared on a set of variables associated with insulin metabolic syndrome: glucose tolerance, triglycerides, blood pressure, and body-mass index. Using insulin resistance as a covariate eliminated these group differences, suggesting that insulin resistance is the key factor underlying insulin metabolic syndrome. The higher risk of later developing type 2 diabetes and hypertension in women who have a history of gestational diabetes is explicable by their poorer profile on variables associated with insulin metabolic syndrome, and appears to be attributable to insulin resistance. Thus, insulin resistance appears to distinguish young women at risk for cardiovascular disease. Copyright (C) 1999 Elsevier Science Inc.
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U2 - 10.1016/S1056-8727(99)00048-3
DO - 10.1016/S1056-8727(99)00048-3
M3 - Article
C2 - 10616862
AN - SCOPUS:0032763515
SN - 1056-8727
VL - 13
SP - 216
EP - 223
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 4
ER -