@article{d688272df89b462cb06510dbe027b51a,
title = "HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis",
abstract = "We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.",
keywords = "Drug resistance, Fitness cost, HIV-TB coinfection, Mycobacterium tuberculosis, Rifampicin",
author = "Chlo{\'e} Loiseau and Daniela Brites and Miriam Reinhard and Kathrin Z{\"u}rcher and Sonia Borrell and Marie Ballif and Lukas Fenner and Helen Cox and Rutaihwa, {Liliana K.} and Wilkinson, {Robert J.} and Marcel Yotebieng and {Jane Carter}, E. and Alashle Abimiku and Olivier Marcy and Eduardo Gotuzzo and Anchalee Avihingsanon and Nicola Zetola and Basra Doulla and B{\"o}ttger, {Erik C.} and Matthias Egger and Sebastien Gagneux",
note = "Funding Information: This research was supported by the Swiss National Science Foundation (grant numbers 153442, 310030_188888, 174281, and IZRJZ3_164171). The International Epidemiology Databases to Evaluate AIDS (IeDEA) is supported by the U.S. National Institutes of Health{\textquoteright}s National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Diabetes and Digestive and Kidney Diseases, the Fogarty International Center, and the National Library of Medicine: Funding Information: Asia-Pacific, U01AI069907; CCASAnet, U01AI069923; Central Africa, U01AI096299; East Africa, U01AI069911; NA-ACCORD, U01AI069918; Southern Africa, U01AI069924; and West Africa, U01AI069919. Informatics resources are supported by the Harmonist Project, R24AI124872. This work is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. R.J.W. is supported by the Francis Crick Institute, which receives funding from Wellcome (FC0010218), CRUK (FC0010218), and UKR1 (FC0010218). He is also supported by Wellcome (104803 and 203135). Publisher Copyright: Copyright {\textcopyright} 2020 Loiseau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",
year = "2020",
month = oct,
doi = "10.1128/AAC.00782-20",
language = "English (US)",
volume = "64",
journal = "Antimicrobial agents and chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "10",
}
