Abstract
This report describes a case of a highly sensitized patient who had serum antibodies reacting with HLA-A2 but whose phenotype included HLA-A2. The determination of HLA mismatch acceptability at the antigen level was problematic, but high-resolution HLA typing information and epitope-based antibody specificity analysis based on the nonself-self paradigm of HLA epitope immunogenicity have provided a solution. This case supports the concept that HLA typing at the allele level offers a better approach to identifying suitable donors for sensitized patients.
Original language | English (US) |
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Pages (from-to) | 141 |
Number of pages | 1 |
Journal | Transplant Immunology |
Volume | 32 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2015 |
Externally published | Yes |
Keywords
- Antibody analysis
- Epitope
- HLA
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Transplantation