HLA Antigens in Lichen Sclerosus et Atrophicus

Karla G. Purcell; Linda V. Spencer; Pippa M. Simpson; Sandra W. Helman; John W. Oldfather; Joseph F. Fowler

doi:10.1001/archderm.1990.01670320067010

HLA Antigens in Lichen Sclerosus et Atrophicus

Karla G. Purcell, Linda V. Spencer, Pippa M. Simpson, Sandra W. Helman, John W. Oldfather, Joseph F. Fowler

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Several reports have found conflicting data regarding the association between lichen sclerosus et atrophicus (LSA) and HLA types. Association with HLA-A31 and -B40 has been noted, whereas another report found no correlation. We are the first to specifically examine HLA types in white patients in the United States. We have found a significant association between LSA and HLA-A29 and -B44 individually and an even stronger association with the combination of A29 and B44. A review of previous LSA-HLA studies, as well as several reports of HLA typing in familial LSA, is discussed, with consideration given to possible reasons for the discrepancies among the various studies.

Original language	English (US)
Pages (from-to)	1043-1045
Number of pages	3
Journal	Archives of Dermatology
Volume	126
Issue number	8
DOIs	https://doi.org/10.1001/archderm.1990.01670320067010
State	Published - Aug 1990
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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abstract = "Several reports have found conflicting data regarding the association between lichen sclerosus et atrophicus (LSA) and HLA types. Association with HLA-A31 and -B40 has been noted, whereas another report found no correlation. We are the first to specifically examine HLA types in white patients in the United States. We have found a significant association between LSA and HLA-A29 and -B44 individually and an even stronger association with the combination of A29 and B44. A review of previous LSA-HLA studies, as well as several reports of HLA typing in familial LSA, is discussed, with consideration given to possible reasons for the discrepancies among the various studies.",

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AU - Oldfather, John W.

AU - Fowler, Joseph F.

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AB - Several reports have found conflicting data regarding the association between lichen sclerosus et atrophicus (LSA) and HLA types. Association with HLA-A31 and -B40 has been noted, whereas another report found no correlation. We are the first to specifically examine HLA types in white patients in the United States. We have found a significant association between LSA and HLA-A29 and -B44 individually and an even stronger association with the combination of A29 and B44. A review of previous LSA-HLA studies, as well as several reports of HLA typing in familial LSA, is discussed, with consideration given to possible reasons for the discrepancies among the various studies.

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HLA Antigens in Lichen Sclerosus et Atrophicus

Abstract

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