@article{3aa5b9f1ca754768be04998f0c766178,
title = "HLA-G and humanized mouse models as a novel therapeutic approach in transplantation",
abstract = "HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation. Here, we critically review the data supporting the tolerogenic role of HLA-G in organ transplantation, the various factors influencing its expression, and the introduction of novel humanized mouse models that are one of the best approaches to assess the utility of HLA-G as a therapeutic tool in organ transplantation.",
keywords = "HLA-G, Humanized mouse model, Rejection, Transplantation",
author = "Ashwin Ajith and Vera Portik-Dobos and Horuzsko, {Daniel D.} and Rajan Kapoor and Mulloy, {Laura L.} and Anatolij Horuzsko",
note = "Funding Information: The authors thank Dr. R.B. Markowitz (Georgia Cancer Center, Augusta University) for critically reading the manuscript. The authors are grateful to the Department Medicine and the Georgia Cancer Center at the Augusta University community for fruitful discussion and support. Figs. 1–3 were created with BioRender (Toronto, Canada). This work was supported by the Carlos and Marguerite Mason Trust, and by U.S. National Institutes of Health, National Cancer Institute Grant CA 172230 (to A.H.). The authors declare that there is no conflict of interest. Funding Information: The authors thank Dr. R.B. Markowitz (Georgia Cancer Center, Augusta University) for critically reading the manuscript. The authors are grateful to the Department Medicine and the Georgia Cancer Center at the Augusta University community for fruitful discussion and support. Figs. 1–3 were created with BioRender (Toronto, Canada). This work was supported by the Carlos and Marguerite Mason Trust , and by U.S. National Institutes of Health, National Cancer Institute Grant CA 172230 (to A.H.). Publisher Copyright: {\textcopyright} 2020 American Society for Histocompatibility and Immunogenetics",
year = "2020",
month = apr,
doi = "10.1016/j.humimm.2020.02.006",
language = "English (US)",
volume = "81",
pages = "178--185",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "4",
}