Abstract
HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation. Here, we critically review the data supporting the tolerogenic role of HLA-G in organ transplantation, the various factors influencing its expression, and the introduction of novel humanized mouse models that are one of the best approaches to assess the utility of HLA-G as a therapeutic tool in organ transplantation.
Original language | English (US) |
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Pages (from-to) | 178-185 |
Number of pages | 8 |
Journal | Human Immunology |
Volume | 81 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2020 |
Keywords
- HLA-G
- Humanized mouse model
- Rejection
- Transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology